Search Result

Search Results for " low-density lipoprotein receptor "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T15561	Imanixil	HOE-402(free base)	Others
	Imanixil is an inducer of the LDL receptor (LDLR) and it is also a potent cholesterol-lowering compound. It also inhibits very low density-lipoprotein (VLDL) production and consequently decreases atherosclerosis developm...		Others
T28009	ME-3221	ME3221
	Apomine is an inhibitor of HMG-CoA-reductase. It promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo. Apomine enhances the antitumor effects of lovastatin on myeloma cells ...
T72025	PCSK9-IN-10		Serine/threonin kinase
	PCSK9-IN-10, a potent and orally active inhibitor of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9), exhibits a half-maximal inhibitory concentration (IC50) of 6.4 µM. By enhancing the expression of Low-Density Li...		Serine/threonin kinase
T26644	Apomine	SK&F-99085,APB-231-A2,APB-231-A-2,SR-9223i,SK&F-99085,SR-45023A	HMG-CoA Reductase
	Apomine (SR-9223i), an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and has been implicated in the regulation of myeloma in vivo. Apomine accelerates the degradation of 3-hydroxy-3-methylg...		HMG-CoA Reductase
T74577	Milpocitide
	Milpocitide, a (293-333)-peptide fragment of the human low-density lipoprotein receptor (LDLR), specifically corresponds to the EGF-like domain 1 [1].
T36180	Azelaoyl PAF
	Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPARγ. One of these substances was recently isolated and pur...
T36171	KDdiA-PC
	Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as ...
T77144	Recaticimab
	Recaticimab (SHR-1209) is a humanized monoclonal antibody targeting PCSK9 to enhance the degradation of this enzyme. By binding to PCSK9, Recaticimab elevates low-density lipoprotein (LDL) receptor presence on hepatocyte...
T78034	ANG1005
	ANG1005 is a brain-penetrating peptide-agent conjugate comprising a taxane derivative that features three paclitaxel molecules covalently bonded to Angiopep-2. This design facilitates crossing of the blood-brain and bloo...
T62598	Pitavastatin sodium
	Pitavastatin (NK-104) sodium is a potent inhibitor of hydroxymethylglutaryl-CoA (HMG-CoA) reductase and a potent inducer of the hepatocyte low-density lipoprotein cholesterol (LDL-C) receptor. pitavastatin sodium inhibit...

Compounds

Imanixil

T15561

Synonym: HOE-402(free base)

Target: Serine/threonin kinase

Apomine

T26644

Synonym: SK&F-99085,APB-231-A2,APB-231-A-2,SR-9223i,SK&F-99085,SR-45023A

Target: HMG-CoA Reductase

Cat No.	Product Name	Targets
T5S0246	Pseudoprotodioscin	Others , Fatty Acid Synthase
	1. Pseudoprotodioscin has moderate cytotoxicity.	Others , Fatty Acid Synthase
T77289	5-O-Methylembelin
	5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9 , low-density lipoprotein receptor (IDOL) , and sterol regulatory element binding protein 2 (SREBP2) mRNA expression [1] .
T36563	(E)-Guggulsterone
	Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulat...

Natural Products

Pseudoprotodioscin

T5S0246

Synonym:

Target: Others, Fatty Acid Synthase

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-00989	LDLR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	LDLR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86 kDa and the accession number is A0A024R7D5.
TMPY-01085	VLDLR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	The very low density lipoprotein receptor, known as VLDLR, is a single-pass type 1 integral membrance protein and a member of the LDL receptor family. This receptor family includes LDL receptor, LRP, megalin, VLDLR and A...
TMPY-01014	LDLR Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	LDLR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 85.7 kDa and the accession number is P35951.
TMPY-05348	LDLR Protein, Mouse, Recombinant (His), Biotinylated	Mouse	HEK293 Cells
	LDLR Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 85.7 kDa and the accession number is P35951.
TMPJ-00394	LDLR Protein, Human, Recombinant (Avi & His), Biotinylated	Human	HEK293 Cells
	Low-density lipoprotein receptor 9 (LDL receptor) is a single-pass type I membrane protein which belongs to the LDLR family. It contains 3 EGF-like domains, 7 LDL-receptor class A domains, and 6 LDL-receptor class B repe...
TMPY-05323	LDLR Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	LDLR Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 111.2 kDa and the accession number is A0A024R7D5.
TMPY-05499	LDLR Protein, Human, Recombinant (His), Biotinylated	Human	HEK293 Cells
	LDLR Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86 kDa and the accession number is A0A024R7D5.
TMPY-05809	LDLR Protein, Human, Recombinant (193D/A, His)	Human	HEK293 Cells
	LDLR Protein, Human, Recombinant (193D/A, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86.19 kDa and the accession number is A0A024R7D5.
TMPY-03351	LOX-1 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	LOX-1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.9 kDa and the accession number is G7PJT2.
TMPY-00383	LDLRAD3 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	LDLRAD3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.8 kDa and the accession number is Q86YD5-1.
TMPY-03975	LRP-11 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	LRP-11 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.3 kDa and the accession number is Q86VZ4-1.
TMPY-04066	LOX-1 Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	LOX-1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.9 kDa and the accession number is O70156.
TMPY-03371	LOX-1 Protein, Rat, Recombinant (hFc)	Rat	HEK293 Cells
	LOX-1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 63.9 kDa and the accession number is O70156.
TMPY-02748	LRP-10 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	LRP-10 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47.5kDa and the accession number is Q7Z4F1-1.
TMPY-02653	LRP-10 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	LRP-10 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73 kDa and the accession number is Q7Z4F1-1.
TMPJ-01412	LRP-12 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Low-Density Lipoprotein Receptor-Related Protein 12 (LRP12) belongs to the LDLR family. LRP12 is a type I transmembrane protein annd widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas. LRP12 c...
TMPY-02490	LOX-1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	LOX-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is P78380.
TMPY-01732	LRPAP1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	LRPAP1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.4 kDa and the accession number is P55302.
TMPY-01233	LRPAP1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	LRPAP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.2 kDa and the accession number is P30533.
TMPJ-00756	Apolipoprotein E/APOE3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	ApoE, a glycoprotein, is a structural component of very low density lipoprotein (vLDL) synthesized by the liver and intestinally synthesized chylomicrons . ApoE is also a constituent of a subclass of high density of lipo...
TMPK-01297	LDLR Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	The low density lipoprotein receptor (LDLR) is the founding member of the LDL R family of widely expressed cell surface scavenger receptors. It is a cell-surface receptor that recognizes the apoprotein B100 which is embe...
TMPK-00402	LDLR Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	The low density lipoprotein receptor (LDLR) is the founding member of the LDL R family of widely expressed cell surface scavenger receptors. It is a cell-surface receptor that recognizes the apoprotein B100 which is embe...
TMPK-00744	LRP-6 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	Dickkopf-related protein 1 (DKK-1), a ligand for the WNT coreceptors low-density lipoprotein receptor-related proteins 5 and 6 (LRP-5 and LRP-6) and an inhibitor of WNT/β-catenin signaling, effectively inhibits pericyte ...
TMPJ-00443	PCSK9 Protein, Macaca nemestrina, Recombinant (His)	Macaca nemestrina	HEK293 Cells
	Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in ...
TMPK-01155	MANSC1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	MANSC1 contains 1 MANSC domain. MANSC is a seven-cysteine-containing domain present in animal membrane and extracellular proteins. MANSC (motif at N terminus with seven cysteines) is a novel domain with a well-conserved ...
TMPK-00740	LRP-5 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that ...
TMPK-00739	LRP-5 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that ...